This FOA invites applications to develop sensitive technologies or methods for obtaining high quality and comprehensive nucleic acids-based genomic data from limited quantities of human specimens that are easy to collect, handle, and store. Applications that address all of the steps from the collection of specimens, through storage and nucleic acids extraction, to obtaining genomic data will be considered as having highest priority to this FOA. The ease of proposed sample collection methods should be at least comparable to that of the current dried blood spot collection method. The developed technologies or methods should be applicable to clinical point-of-care testing in terms of speed and ease, and ultimately have the potential to be scalable to high throughput settings, while maintaining cost effectiveness. The genomic data obtained must be at least equivalent to that which can be obtained from fresh whole blood in terms of quality and comprehensiveness. It is expected that the research conducted under this FOA will enhance the availability of comprehensive nucleic acids-based genomic data for various clinical and research applications in need of obtaining genomic data from easy-to-collect and handle human specimens
PAR-13-203)National Human Genome Research Institute Eunice Kennedy Shriver National Institute of Child Health and Human Development Application Receipt Date(s): July 29, 2013; December 2, 2013; March 26, 2014; July 29, 2014; December 2, 2014; March 26, 2015; July 29, 2015; December 2, 2015; March 25, 2016